Here’s my first ever bit of rumor mongering!
It has previously been reported that Duke Nukem Forever is going to use the Meqon physics engine. Well, last year, Meqon was purchased by AGEIA. Now AGEIA is the maker of the PhysX physics accelerator card. So putting 2 and 2 together seems to me to lead to the conclusion that Duke Nukem Forever will use the PhysX card.
Of course that all depends on whether or not Duke Nukem ever comes out and if AGEIA is still around when Duke Nukem Forever finally comes out…